MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006742

UniProt Annotations

Entry Information
Gene Namelactate dehydrogenase D
Protein EntryLDHD_HUMAN
UniProt IDQ86WU2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 {ECO:0000269|PubMed:15489334}; IsoId=Q86WU2-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:12127981}; IsoId=Q86WU2-2; Sequence=VSP_052253;
Catalytic Activity(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:P39976};
Sequence CautionSequence=AAM50322.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityBelongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000255}.
SimilarityContains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}.
Subcellular LocationMitochondrion {ECO:0000250|UniProtKB:Q7TNG8}.
SubunitInteracts with CSRP3. {ECO:0000269|PubMed:12127981}.
Tissue SpecificityExpressed moderately in heart and liver and at lower levels in skeletal muscle and kidney. {ECO:0000269|PubMed:12127981}.
  logo