MGP Database

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MGP006855

UniProt Annotations

Entry Information
Gene NameATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
Protein EntryVA0D2_HUMAN
UniProt IDQ8N8Y2
SpeciesHuman
Comments
Comment typeDescription
FunctionSubunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). {ECO:0000250}.
SimilarityBelongs to the V-ATPase V0D/AC39 subunit family. {ECO:0000305}.
SubunitV-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Tissue SpecificityKidney, osteoclast and lung. {ECO:0000269|PubMed:12384298}.
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