MGP Database

MGP006865

Record overview

MGPD ID	MGP006865
Gene ID	253559
Species	Homo sapiens (Human)
Gene Name	cell adhesion molecule 2
Gene Symbol	CADM2
Synonyms	NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2;
Alternate names	cell adhesion molecule 2; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4D; nectin-like 3; nectin-like protein 3; synaptic cell adhesion molecule 2;
Chromosome	3
Map Location	3p12.1
Summary	This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Orthologs	View orthologs and multiple alignments for CADM2

Proteins

cell adhesion molecule 2 isoform 1 precursor

Refseq ID:	NP_001161146
Protein GI:	264681533
UniProt ID:	Q8N3J6
mRNA ID:	NM_001167674
Length:	435
RefSeq Status:

MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEG
QYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVA
VICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATN
TIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYL
TNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI

sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1709
peptide sequence: 
MFVLFLCNLSLVPAAA

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2684
peptide sequence: 
MIWKRSAVLRFYSVCGLLLQAAAS

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2713
peptide sequence: 
MIWKRSAVLRFYSVCGLLLQGSQG

mat_peptide: 25..435
product: Cell adhesion molecule 2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q8N3J6.1)
calculated_mol_wt: 44859
peptide sequence: 
QFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVP
EKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIH
YTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTT
IIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQ
VNAEEKKEYFI

cell adhesion molecule 2 isoform 2 precursor

Refseq ID:	NP_001161147
Protein GI:	264681535
UniProt ID:	Q8N3J6
mRNA ID:	NM_001167675
Length:	404
RefSeq Status:

MIWKRSAVLRFYSVCGLLLQAAASKNKVKGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISV
SDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFR
VDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDN
GTYRCEATNTIGQSSAEYVLIVHDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKK
EYFI

sig_peptide: 1..16
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1709
peptide sequence: 
MFVLFLCNLSLVPAAA

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2684
peptide sequence: 
MIWKRSAVLRFYSVCGLLLQAAAS

cell adhesion molecule 2 isoform 3 precursor

Refseq ID:	NP_694854
Protein GI:	54607031
UniProt ID:	Q8N3J6
mRNA ID:	NM_153184
Length:	437
RefSeq Status:

MFVLFLCNLSLVPAAASKNKVKGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSD
EGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDG
VAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEA
TNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGT
YLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI

cell adhesion molecule 2 isoform 4
`sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1709 peptide sequence: MFVLFLCNLSLVPAAA`

Refseq ID:	NP_001243431
Protein GI:	374671754
UniProt ID:	Q8N3J6
mRNA ID:	NM_001256502
Length:	327
RefSeq Status:

cell adhesion molecule 2 isoform 4
`MPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHE SLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAE YVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAE DAPDADTAIINAEGSQVNAEEKKEYFI`

Refseq ID:	NP_001243432
Protein GI:	374671756
UniProt ID:	Q8N3J6
mRNA ID:	NM_001256503
Length:	327
RefSeq Status:

cell adhesion molecule 2 isoform 5
Protein sequence is identical to GI:374671754 (mRNA isoform)

Refseq ID:	NP_001243433
Protein GI:	374671758
UniProt ID:	Q8N3J6
mRNA ID:	NM_001256504
Length:	287
RefSeq Status:

cell adhesion molecule 2 isoform 5
`MPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHE SLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAE YVLIVHDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI`

Refseq ID:	NP_001243434
Protein GI:	374671760
UniProt ID:	Q8N3J6
mRNA ID:	NM_001256505
Length:	287
RefSeq Status:

Protein sequence is identical to GI:374671758 (mRNA isoform)