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MGP006890

Record overview

MGPD IDMGP006890
Gene ID256297
SpeciesHomo sapiens (Human)
Gene Namepancreas specific transcription factor, 1a
Gene Symbol PTF1A
SynonymsPACA; PAGEN2; bHLHa29; PTF1-p48;
Alternate namespancreas transcription factor 1 subunit alpha; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas-specific transcription factor 1a;
Chromosome10
Map Location10p12.2
SummaryThis gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PTF1A

Proteins

pancreas transcription factor 1 subunit alpha
Refseq ID:NP_835455
Protein GI:30039710
UniProt ID:Q7RTS3
mRNA ID:NM_178161
Length:328
RefSeq Status:
MDAVLLEHFPGGLDAFPSSYFDEDDFFTDQSSRDPLEDGDELLADEQAEVEFLSHQLHEYCYRDGACLLLQPAPPAAPLALAPPSSGGLGEPDDGGGGGY
CCETGAPPGGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLS
KVDTLRLAIGYINFLSELVQADLPLRGGGAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKV
WTPEDPRKLNSKSSFNNIENEPPFEFVS
 
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