MGP Database

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MGP006935

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IVD (cytosolic)
Protein EntryPA24D_HUMAN
UniProt IDQ86XP0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86XP0-1; Sequence=Displayed; Name=2; IsoId=Q86XP0-2; Sequence=VSP_019881, VSP_019882; Note=May be due to an intron retention. Ref.2 (AAH34571) sequence is in conflict in position: 713:G->R. {ECO:0000305};
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme RegulationStimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:14709560}.
FunctionCalcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269|PubMed:14709560}.
Sequence CautionSequence=AAH34571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular LocationCytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. {ECO:0000269|PubMed:14709560}.
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