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MGP006986

UniProt Annotations

Entry Information
Gene Namechondroitin sulfate synthase 3
Protein EntryCHSS3_HUMAN
UniProt IDQ70JA7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-glucuronate + N-acetyl-beta-D- galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan.
Catalytic ActivityUDP-N-acetyl-alpha-D-galactosamine + beta-D- glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.
CofactorName=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:12907687}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:12907687}; Name=Cd(2+); Xref=ChEBI:CHEBI:48775; Evidence={ECO:0000269|PubMed:12907687}; Note=Divalent metal cations. Highest activities are measured with Co(2+), Mn(2+) and Cd(2+). {ECO:0000269|PubMed:12907687};
FunctionHas both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269|PubMed:12907687}.
Sequence CautionSequence=CAD43233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the chondroitin N- acetylgalactosaminyltransferase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:12907687}; Single-pass type II membrane protein {ECO:0000305|PubMed:12907687}.
Tissue SpecificityDetected at low levels in brain, cerebral cortex, uterus and small intestine. {ECO:0000269|PubMed:12907687}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Chondroitin sulfate synthase 3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_446";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CSS3";
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