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MGP006998

UniProt Annotations

Entry Information
Gene Nameectonucleotide pyrophosphatase/phosphodiesterase 7
Protein EntryENPP7_HUMAN
UniProt IDQ6UWV6
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine. {ECO:0000269|PubMed:12885774}.
Enzyme RegulationInhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA. {ECO:0000269|PubMed:12885774}.
FunctionConverts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. {ECO:0000269|PubMed:12885774}.
MiscellaneousDecreased levels of alkaline sphingomyelin phosphodiesterase may be associated with colon cancer. {ECO:0000303|PubMed:12671034, ECO:0000303|PubMed:15016655}.
PtmN-glycosylated; required for activity and transport to the plasma membrane. {ECO:0000269|PubMed:15458386, ECO:0000269|PubMed:19159218}.
SimilarityBelongs to the nucleotide pyrophosphatase/phosphodiesterase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:12671034, ECO:0000305}; Single-pass type I membrane protein {ECO:0000269|PubMed:12671034, ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Tissue SpecificityDetected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. {ECO:0000269|PubMed:12671034, ECO:0000269|PubMed:12885774}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ENPP7ID44055ch17q25.html";
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