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MGP007078

Record overview

MGPD IDMGP007078
Gene ID387522
SpeciesHomo sapiens (Human)
Gene NameTMEM189-UBE2V1 readthrough
Gene Symbol TMEM189-UBE2V1
SynonymsCROC1B; CROC-1B; KUA-UEV;
Alternate namesTMEM189-UBE2V1 fusion protein; TMEM189-UBE2V1 readthrough transcript; transmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through;
Chromosome20
Map Location20q13.2
SummaryThe TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
OrthologsView orthologs and multiple alignments for TMEM189-UBE2V1

Proteins

TMEM189-UBE2V1 fusion protein
Refseq ID:NP_954673
Protein GI:40806190
UniProt ID:Q13404
mRNA ID:NM_199203
Length:370
RefSeq Status:
MAGAEDWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRLQEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADT
WGSVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPEALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVT
LLQDWHVILPRKHHRIHHVSPHETYFCITTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPE
APPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN
 
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