Summary of Study ST002066
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001308. The data can be accessed directly via it's Project DOI: 10.21228/M8N98X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002066 |
Study Title | Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer |
Study Type | Biomedical research |
Study Summary | To characterize the impact of KRAS co-mutations KEAP1 and STK11/Lkb1 on the metabolic and immune microenvironment of lung adenocarcinoma in immune-intact models, we generated a cohort of genetically engineered mouse models (GEMMs) to reflect the diverse tumor suppressor landscape seen in patients. Mice carrying the KrasG12D allele (K)21 were crossed with Keap1flox/flox (KK)22 and/or Lkb1flox/flox (KKL, KL)23 mice and genetic recombination induced by intranasal inhalation of Ad5-CMV-Cre adenovirus. We interrogated the metabolites present in lung tumor nodules collected from cohorts of KK, KL and KKL mice. |
Institute | The Walter and Eliza Hall Institute of Medical Research |
Laboratory | Kate Sutherland |
Last Name | Sarah |
First Name | Best |
Address | 1G, Royal Parade, Parkville VIC 3052, Australia |
best@wehi.edu.au | |
Phone | +61-3-9345-2452 |
Submit Date | 2022-01-18 |
Num Groups | 5 |
Total Subjects | 25 |
Num Males | 17 |
Num Females | 8 |
Study Comments | L lobe of mice lung |
Publications | Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2022-05-02 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | treatment |
---|---|---|
SA194269 | Blank_1 | Extraction blank |
SA194270 | Blank_4 | Extraction blank |
SA194271 | Blank_3 | Extraction blank |
SA194272 | Blank_2 | Extraction blank |
SA194273 | K_5 | Kras |
SA194274 | K_4 | Kras |
SA194275 | K_1 | Kras |
SA194276 | K_2 | Kras |
SA194277 | K_3 | Kras |
SA194278 | KK_5 | Kras/Keap1 |
SA194279 | KK_4 | Kras/Keap1 |
SA194280 | KK_3 | Kras/Keap1 |
SA194281 | KK_2 | Kras/Keap1 |
SA194282 | KKL_5 | Kras/Keap1/Lkb1 |
SA194283 | KKL_4 | Kras/Keap1/Lkb1 |
SA194284 | KKL_3 | Kras/Keap1/Lkb1 |
SA194285 | KKL_1 | Kras/Keap1/Lkb1 |
SA194286 | KL_5 | Kras/Lkb1 |
SA194287 | KL_4 | Kras/Lkb1 |
SA194288 | KL_3 | Kras/Lkb1 |
SA194289 | KL_1 | Kras/Lkb1 |
SA194290 | KL_2 | Kras/Lkb1 |
SA194291 | KP_3 | Kras/p53 |
SA194292 | KP_4 | Kras/p53 |
SA194293 | KP_2 | Kras/p53 |
SA194294 | QC_4 | QC |
SA194295 | QC_3 | QC |
SA194296 | QC_2 | QC |
SA194297 | QC_1 | QC |
SA194299 | KK_1 | YFP(WT)/Kras/Keap1/p53(WT) |
SA194298 | KP_1 | YFP(WT)/Kras/Keap1(WT)/p53 |
Showing results 1 to 31 of 31 |