Summary of Study ST002066
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001308. The data can be accessed directly via it's Project DOI: 10.21228/M8N98X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002066 |
Study Title | Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer |
Study Type | Biomedical research |
Study Summary | To characterize the impact of KRAS co-mutations KEAP1 and STK11/Lkb1 on the metabolic and immune microenvironment of lung adenocarcinoma in immune-intact models, we generated a cohort of genetically engineered mouse models (GEMMs) to reflect the diverse tumor suppressor landscape seen in patients. Mice carrying the KrasG12D allele (K)21 were crossed with Keap1flox/flox (KK)22 and/or Lkb1flox/flox (KKL, KL)23 mice and genetic recombination induced by intranasal inhalation of Ad5-CMV-Cre adenovirus. We interrogated the metabolites present in lung tumor nodules collected from cohorts of KK, KL and KKL mice. |
Institute | The Walter and Eliza Hall Institute of Medical Research |
Laboratory | Kate Sutherland |
Last Name | Sarah |
First Name | Best |
Address | 1G, Royal Parade, Parkville VIC 3052, Australia |
best@wehi.edu.au | |
Phone | +61-3-9345-2452 |
Submit Date | 2022-01-18 |
Num Groups | 5 |
Total Subjects | 25 |
Num Males | 17 |
Num Females | 8 |
Study Comments | L lobe of mice lung |
Publications | Glutaminase inhibition impairs CD8 T cell activation in STK11/Lkb1 deficient lung cancer |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2022-05-02 |
Release Version | 1 |
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Collection:
Collection ID: | CO002141 |
Collection Summary: | At defined timepoints (K: 90 days, KK: 60 days, KL and KKL: 40 days post Ad5-CMV-Cre), mice were sacrificed by cardiac puncture and lungs and plasma harvested for downstream analysis. |
Sample Type: | Lung |
Storage Conditions: | -80℃ |