Summary of Study ST000305

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000245. The data can be accessed directly via it's Project DOI: 10.21228/M8401H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST000305
Study TitlePig Athersclerosis Model
Study TypeMetabolomics
Study SummaryInsulin-resistant subjects develop more severe and diffuse coronary artery atherosclerosis than insulin sensitive control but the mechanisms that mediate the atherosclerosis phenotype are unknown. The objective of this study is to investigate whether the severity of atherosclerosis is associated not only with lipoprotein concentrations, weight, blood pressure, biomarkers of inflammation and IR in an animal model but also changes in parameters that measure protein glycation. The experimental approach was to study normocholestrolemic pigs fed a high fat diet that also contained increased NaCl. The choice of pigs was driven by the fact that, like humans, they develop coronary artery and aortic atherosclerosis and insulin resistance. In addition, pigs have been used in many studies to define the mechanisms that mediate increased atherosclerosis in diabetes.
Institute
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Emailsusan_sumner @unc.edu
Phone704-250-5066
Submit Date2015-12-31
Total Subjects90
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2016-12-31
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8401H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Sus scrofa (Factor headings shown in green)

mb_sample_id local_sample_id atherosclerosis diet phenotype sex
SA013757FN_46LLittle to None Control CH/FH female
SA013758FN_22ILittle to None Control CH/FH female
SA013759BN_46LLittle to None Control CH/FH female
SA013760BN_22ILittle to None Control CH/FH female
SA013761BN_05KLittle to None Control CH/FH male
SA013762FN_05KLittle to None Control CH/FH male
SA013763FN_18KLittle to None Control CH female
SA013764BN_18KLittle to None Control CH female
SA013765BN_16KLittle to None Control CH male
SA013766FN_16KLittle to None Control CH male
SA013767BM_08KModerate High fat and salt CH/FH female
SA013768FM_08KModerate High fat and salt CH/FH female
SA013769FM_01FModerate High fat and salt CH/FH male
SA013770BM_69GModerate High fat and salt CH/FH male
SA013771BM_21JModerate High fat and salt CH/FH male
SA013772BM_14KModerate High fat and salt CH/FH male
SA013773FM_02FModerate High fat and salt CH/FH male
SA013774FM_05IModerate High fat and salt CH/FH male
SA013775FM_20JModerate High fat and salt CH/FH male
SA013776FM_14KModerate High fat and salt CH/FH male
SA013777FM_69GModerate High fat and salt CH/FH male
SA013778FM_21JModerate High fat and salt CH/FH male
SA013779BM_20JModerate High fat and salt CH/FH male
SA013780BM_01FModerate High fat and salt CH/FH male
SA013781BM_06IModerate High fat and salt CH/FH male
SA013782BM_02FModerate High fat and salt CH/FH male
SA013783BM_05IModerate High fat and salt CH/FH male
SA013784FM_11GModerate High fat and salt CH female
SA013785BM_11GModerate High fat and salt CH female
SA013786FM_69FModerate High fat and salt CH male
SA013787FM_62FModerate High fat and salt CH male
SA013788FM_45LModerate High fat and salt CH male
SA013789FM_15KModerate High fat and salt CH male
SA013790FM_68FModerate High fat and salt CH male
SA013791FM_02CModerate High fat and salt CH male
SA013792BM_62FModerate High fat and salt CH male
SA013793BM_45LModerate High fat and salt CH male
SA013794BM_15KModerate High fat and salt CH male
SA013795BM_02CModerate High fat and salt CH male
SA013796BM_69FModerate High fat and salt CH male
SA013797Mod_FU_Pool2Moderate Pool
SA013798Mod_Base_Pool1Moderate Pool
SA013799Mod_Base_Pool2Moderate Pool
SA013800Mod_FU_Pool1Moderate Pool
SA013801Total_FU_Pool3Pool Pool
SA013802Total_Base_Pool5Pool Pool
SA013803FS_10KSevere & Diffuse High fat and salt CH/FH female
SA013804FS_18JSevere & Diffuse High fat and salt CH/FH female
SA013805FS_17KSevere & Diffuse High fat and salt CH/FH female
SA013806FS_24ISevere & Diffuse High fat and salt CH/FH female
SA013807FS_07KSevere & Diffuse High fat and salt CH/FH female
SA013808BS_49LSevere & Diffuse High fat and salt CH/FH female
SA013809FS_02ISevere & Diffuse High fat and salt CH/FH female
SA013810FS_03ISevere & Diffuse High fat and salt CH/FH female
SA013811FS_06FSevere & Diffuse High fat and salt CH/FH female
SA013812FS_09KSevere & Diffuse High fat and salt CH/FH female
SA013813BS_10KSevere & Diffuse High fat and salt CH/FH female
SA013814BS_24ISevere & Diffuse High fat and salt CH/FH female
SA013815BS_07KSevere & Diffuse High fat and salt CH/FH female
SA013816BS_09KSevere & Diffuse High fat and salt CH/FH female
SA013817BS_18JSevere & Diffuse High fat and salt CH/FH female
SA013818BS_03ISevere & Diffuse High fat and salt CH/FH female
SA013819BS_02ISevere & Diffuse High fat and salt CH/FH female
SA013820FS_49LSevere & Diffuse High fat and salt CH/FH female
SA013821BS_17KSevere & Diffuse High fat and salt CH/FH female
SA013822FS_21ISevere & Diffuse High fat and salt CH/FH male
SA013823FS_02KSevere & Diffuse High fat and salt CH/FH male
SA013824BS_02KSevere & Diffuse High fat and salt CH/FH male
SA013825BS_21ISevere & Diffuse High fat and salt CH/FH male
SA013826FS_48LSevere & Diffuse High fat and salt CH female
SA013827FS_47LSevere & Diffuse High fat and salt CH female
SA013828BS_47LSevere & Diffuse High fat and salt CH female
SA013829FS_05BSevere & Diffuse High fat and salt CH female
SA013830FS_35GSevere & Diffuse High fat and salt CH female
SA013831BS_35GSevere & Diffuse High fat and salt CH female
SA013832BS_48LSevere & Diffuse High fat and salt CH female
SA013833BS_05BSevere & Diffuse High fat and salt CH female
SA013834BS_33GSevere & Diffuse High fat and salt CH male
SA013835BS_44LSevere & Diffuse High fat and salt CH male
SA013836FS_44LSevere & Diffuse High fat and salt CH male
SA013837BS_34GSevere & Diffuse High fat and salt CH male
SA013838FS_33GSevere & Diffuse High fat and salt CH male
SA013839FS_34GSevere & Diffuse High fat and salt CH male
SA013840BS_20ISevere & Diffuse High fat and salt CH male
SA013841Sev_Base_Pool1Severe & Diffuse Pool
SA013842Sev_FU_Pool2Severe & Diffuse Pool
SA013843Sev_FU_Pool1Severe & Diffuse Pool
SA013844Sev_Base_Pool3Severe & Diffuse Pool
SA013845Sev_Base_Pool2Severe & Diffuse Pool
SA013846Sev_FU_Pool3Severe & Diffuse Pool
Showing results 1 to 90 of 90
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