Summary of Study ST001843

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000667. The data can be accessed directly via it's Project DOI: 10.21228/M8FX07 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001843
Study TitleIdentification of unique metabolite networks between Latino and Caucasian patients with nonalcoholic fatty liver disease (NAFLD) (part II)
Study SummaryNonalcoholic fatty liver disease (NAFLD) is a spectrum of liver pathology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH); the latter is characterized by inflammation and fibrosis. Risk factors for NALFD include obesity, diabetes, hyperlipidemia, and hypertension—all of which are features of metabolic syndrome. NAFLD is a very heterogeneous disease, as it presents in different patterns in males and females and in patients from different ethnicities, with unclear predictors for development and severity of disease. Previous studies have shown that NAFLD is 1.4 times more frequent in Hispanics than in Caucasians. One of the major challenges in NAFLD is the lack of accurate, noninvasive biomarkers for the detection of the most aggressive presentation, NASH. The gold standard for the diagnosis is liver biopsy, which is an invasive procedure associated with possible complications. Noninvasive diagnosis of NASH is a major unmet medical need and there are no ethnicity-specific biomarkers that can diagnose this condition and predict its progression. Therefore, the main gap in knowledge that this proposal and line of research will address is the characterizing the different plasma and liver metabolomics profile of patients with fatty liver from two ethnicities (Latinos vs. Caucasians) and of both sexes. The overall hypothesis of the present study is that the higher incidence of nonalcoholic fatty liver (NAFL) in Latino patients is reflected in a different plasma and liver metabolomics profile compared to Caucasian patients with further sex-related differences. Characterization of metabolite networks can aid in identifying the mechanistic underpinnings of sex and ethnic driven differences in NAFL which could help diagnose and establish a prognosis of this condition, especially in the critical transition from NAFL to the more aggressive nonalcoholic steatohepatitis (NASH).To address this hypothesis, plasma metabolomics profile of samples from male and female Latino and Caucasian bariatric surgery patients with NAFL and from healthy subjects will be compared. Metabolomics findings will be related with liver pathology and liver transcriptome profiles from intraoperatively obtained liver biopsies using correlation, network, and pathway analysis.
Institute
University of California, Davis
DepartmentDepartment of Internal Medicine, Division of Gastroenterology and Hepatology
LaboratoryMedici Lab
Last NameMedici
First NameValentina
Address4150 V Street - PSSB Suite 3500 - 95817 Sacramento CA
Emailvmedici@ucdavis.edu
Phone(916) 734 3751
Submit Date2021-06-10
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS
Release Date2021-07-05
Release Version1
Valentina Medici Valentina Medici
https://dx.doi.org/10.21228/M8FX07
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id organ Diagnosis
SA171524BSU-0187Liver NAFLD
SA171525B-1513Liver NAFLD
SA171526B-1342Liver NAFLD
SA171527B-1501Liver NAFLD
SA171528B-1441Liver NAFLD
SA171529B-0286Liver NAFLD
SA171530B-1297Liver NAFLD
SA171531BSU-0146Liver NAFLD
SA171532BSU-0197Liver NAFLD
SA171533B-0193Liver NAFLD
SA171534B-0254Liver NAFLD
SA171535B-0269Liver NAFLD
SA171536B-1405Liver NAFLD
SA171537B-0262Liver NAFLD
SA171538B-1432Liver NAFLD
SA171539B-1371Liver NAFLD
SA171540B-1156Liver NAFLD
SA171541B-1148Liver NAFLD
SA171542B-0945Liver NAFLD
SA171543B-1184Liver NAFLD
SA171544M2Plasma Healthy Control
SA171545HC122Plasma Healthy Control
SA171546HC121Plasma Healthy Control
SA171547HC126Plasma Healthy Control
SA171548K10Plasma Healthy Control
SA171549HC117Plasma Healthy Control
SA171550HC128Plasma Healthy Control
SA171551K9Plasma Healthy Control
SA171552HC105Plasma Healthy Control
SA171553HC127Plasma Healthy Control
SA171554110Plasma Healthy Control
SA171555151Plasma Healthy Control
SA17155680Plasma Healthy Control
SA17155710Plasma Healthy Control
SA1715582Plasma Healthy Control
SA171559175Plasma Healthy Control
SA17156026Plasma Healthy Control
SA171561197Plasma Healthy Control
SA171562343Plasma Healthy Control
SA171563316Plasma Healthy Control
SA171564204Plasma Healthy Control
SA171565236Plasma Healthy Control
SA171566P-3266Plasma NAFLD
SA171567P-3182Plasma NAFLD
SA171568P-0788Plasma NAFLD
SA171569P-0320Plasma NAFLD
SA171570P-0185Plasma NAFLD
SA171571P-1010Plasma NAFLD
SA171572P-0432Plasma NAFLD
SA171573P-1006Plasma NAFLD
SA171574P-0361Plasma NAFLD
SA171575P-3011Plasma NAFLD
SA171576P-3227Plasma NAFLD
SA171577P-3194Plasma NAFLD
SA171578P-3242Plasma NAFLD
SA171579P-0796Plasma NAFLD
SA171580P-3200Plasma NAFLD
SA171581P-3043Plasma NAFLD
SA171582P-3008Plasma NAFLD
SA171583P-2546Plasma NAFLD
Showing results 1 to 60 of 60
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