Summary of Study ST001853

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001166. The data can be accessed directly via it's Project DOI: 10.21228/M80981 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001853
Study TitleLongitudinal Metabolomics of Human Plasma Reveals Robust Prognostic Markers of COVID-19 Disease Severity (Part 2)
Study SummaryThere is an urgent need to identify which COVID-19 patients will develop life-threatening illness so that medical resources can be optimally allocated and rapid treatment can be administered early in the disease course, when clinical management is most effective. To aid in the prognostic classification of disease severity, we perform untargeted metabolomics on plasma from 339 patients, with samples collected at six longitudinal time points. Using the temporal metabolic profiles and machine learning, we build a predictive model of disease severity. We discover that a panel of metabolites measured at the time of study entry successfully determine disease severity. Through analysis of longitudinal samples, we confirm that the majority of these markers are directly related to disease progression and that their levels are restored to baseline upon disease recovery. Finally, we validate that these metabolites are also altered in a hamster model of COVID-19. Our results indicate that metabolic changes associated with COVID-19 severity can be effectively used to stratify patients and inform resource allocation during the pandemic.
Institute
Washington University in St. Louis
DepartmentChemistry
LaboratoryPatti
Last NamePatti
First NameGary
AddressMcMillen Chemistry Laboratory, Washington University 1 Brookings Dr @ Throop Drive, Rm 102, St. Louis, MO 63130-4899
Emailgjpattij@wustl.edu
Phone314-935-3512
Submit Date2021-01-28
Num Groups3
Total Subjects56
Num Females56
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2021-06-30
Release Version1
Gary Patti Gary Patti
https://dx.doi.org/10.21228/M80981
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mesocricetus auratus (Factor headings shown in green)

mb_sample_id local_sample_id Group Day post infection
SA174153P H-473Influenza 14
SA174154P H-497Influenza 14
SA174155P H-499Influenza 14
SA174156P H-496Influenza 14
SA174157P H-467Influenza 14
SA174158P H-483Influenza 14
SA174159P H-502Influenza 2
SA174160P H-505Influenza 2
SA174161P H-492Influenza 2
SA174162P H-506Influenza 2
SA174163P H-474Influenza 2
SA174164P H-478Influenza 2
SA174165P H-457Influenza 4
SA174166P H-458Influenza 4
SA174167P H-460Influenza 4
SA174168P H-433Influenza 4
SA174169P H-466Influenza 4
SA174170P H-498Influenza 4
SA174171P H-486Influenza 6
SA174172P H-477Influenza 6
SA174173P H-491Influenza 6
SA174174P H-462Influenza 6
SA174175P H-461Influenza 6
SA174176P H-515Influenza 6
SA174177P H-501Mock 14
SA174178P H-490Mock 14
SA174179P H-489Mock 14
SA174180P H-475Mock 14
SA174181P H-470Mock 14
SA174182P H-481Mock 14
SA174183P H-507Mock 4
SA174184P H-464Mock 4
SA174185P H-472Mock 4
SA174186P H-482Mock 4
SA174187P H-476Mock 4
SA174188P H-480Mock 4
SA174189P H-510SARS-CoV-2 14
SA174190P H-511SARS-CoV-2 14
SA174191P H-484SARS-CoV-2 14
SA174192P H-459SARS-CoV-2 14
SA174193P H-485SARS-CoV-2 14
SA174194P H-479SARS-CoV-2 14
SA174195P H-513SARS-CoV-2 2
SA174196P H-516SARS-CoV-2 2
SA174197P H-469 -1SARS-CoV-2 2
SA174198P H-514SARS-CoV-2 4
SA174199P H-469 -2SARS-CoV-2 4
SA174200P H-488SARS-CoV-2 4
SA174201P H-471SARS-CoV-2 4
SA174202P H-487SARS-CoV-2 4
SA174203P H-463SARS-CoV-2 6
SA174204P H-509SARS-CoV-2 6
SA174205P H-504SARS-CoV-2 6
SA174206P H-495SARS-CoV-2 6
SA174207P H-468SARS-CoV-2 6
SA174208P H-512SARS-CoV-2 6
Showing results 1 to 56 of 56
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