Summary of Study ST002568
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001655. The data can be accessed directly via it's Project DOI: 10.21228/M8S726 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002568 |
| Study Title | Assessment of metabolic changes in different animal models of maladaptive right ventricular hypertrophy in chronic pulmonary hypertension by lipidomics and HILIC |
| Study Summary | We analyzed plasma samples from 33 Yucatan pigs belonging to four different experimental models of pulmonary hypertension (PH): M1 chronic postcapillary PH by pulmonary vein banding; M2 chronic PH by aorto-pulmonary shunting; M3: right ventricular pressure overload by pulmonary artery banding, thus without PH; and M0 sham procedure. Briefly, blood samples were collected 8 months after surgery and untargeted lipidomics and HILIC metabolomic analyses were performed for negative and positive polarities. For quality control, 5 QC samples were included in each analysis, iterative MSMS was performed for metabolite annotation. Plasma metabolomic patterns differed among groups, displaying arginine-nitric oxide and histidine deficiency in both PH models (M1 and M2), altered taurine and purine pathways in M2, and lipidomic changes in all three models of pressure overload. |
| Institute | Universidad CEU San Pablo |
| Last Name | Moran |
| First Name | Maria |
| Address | Universidad CEU-San Pablo. Urb. Montepríncipe |
| maria.morangarrido@ceu.es | |
| Phone | 913724769 |
| Submit Date | 2023-03-23 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-05-10 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Sus scrofa (Factor headings shown in green)
| mb_sample_id | local_sample_id | Model |
|---|---|---|
| SA258095 | B0_2992_HILIC_negative | M0 |
| SA258096 | A0_7611_HILIC_positive | M0 |
| SA258097 | A0_7573_HILIC_positive | M0 |
| SA258098 | B0_2995_Lipidomics_negative | M0 |
| SA258099 | B0_3219_Lipidomics_negative | M0 |
| SA258100 | B0_5023_Lipidomics_negative | M0 |
| SA258101 | B0_5021_Lipidomics_negative | M0 |
| SA258102 | A0_7348_HILIC_positive | M0 |
| SA258103 | B0_3216_Lipidomics_negative | M0 |
| SA258104 | A0_6952_HILIC_positive | M0 |
| SA258105 | B0_3219_HILIC_positive | M0 |
| SA258106 | B0_3216_HILIC_positive | M0 |
| SA258107 | B0_2995_HILIC_positive | M0 |
| SA258108 | B0_5021_HILIC_positive | M0 |
| SA258109 | B0_5023_HILIC_positive | M0 |
| SA258110 | B0_5247_HILIC_positive | M0 |
| SA258111 | B0_5194_HILIC_positive | M0 |
| SA258112 | B0_5194_Lipidomics_negative | M0 |
| SA258113 | B0_5247_Lipidomics_negative | M0 |
| SA258114 | B0_5247_Lipidomics_positive | M0 |
| SA258115 | B0_5194_Lipidomics_positive | M0 |
| SA258116 | B0_5023_Lipidomics_positive | M0 |
| SA258117 | A0_6952_Lipidomics_positive | M0 |
| SA258118 | A0_7348_Lipidomics_positive | M0 |
| SA258119 | A0_7611_Lipidomics_positive | M0 |
| SA258120 | A0_7573_Lipidomics_positive | M0 |
| SA258121 | B0_5021_Lipidomics_positive | M0 |
| SA258122 | B0_3219_Lipidomics_positive | M0 |
| SA258123 | A0_7573_Lipidomics_negative | M0 |
| SA258124 | A0_7348_Lipidomics_negative | M0 |
| SA258125 | A0_6952_Lipidomics_negative | M0 |
| SA258126 | A0_7611_Lipidomics_negative | M0 |
| SA258127 | B0_2992_Lipidomics_positive | M0 |
| SA258128 | B0_3216_Lipidomics_positive | M0 |
| SA258129 | B0_2995_Lipidomics_positive | M0 |
| SA258130 | B0_2992_HILIC_positive | M0 |
| SA258131 | B0_2992_Lipidomics_negative | M0 |
| SA258132 | B0_5194_HILIC_negative | M0 |
| SA258133 | B0_5021_HILIC_negative | M0 |
| SA258134 | B0_3219_HILIC_negative | M0 |
| SA258135 | B0_5247_HILIC_negative | M0 |
| SA258136 | A0_6952_HILIC_negative | M0 |
| SA258137 | A0_7611_HILIC_negative | M0 |
| SA258138 | A0_7573_HILIC_negative | M0 |
| SA258139 | A0_7348_HILIC_negative | M0 |
| SA258140 | B0_3216_HILIC_negative | M0 |
| SA258141 | B0_5023_HILIC_negative | M0 |
| SA258142 | B0_2995_HILIC_negative | M0 |
| SA258143 | B1_3796_HILIC_negative | M1 |
| SA258144 | B1_3800_HILIC_negative | M1 |
| SA258145 | B1_3801_Lipidomics_positive | M1 |
| SA258146 | A1_7050_HILIC_negative | M1 |
| SA258147 | A1_7049_HILIC_negative | M1 |
| SA258148 | B1_3801_HILIC_negative | M1 |
| SA258149 | B1_3796_Lipidomics_negative | M1 |
| SA258150 | A1_7575_Lipidomics_negative | M1 |
| SA258151 | A1_7130_Lipidomics_negative | M1 |
| SA258152 | A1_7049_Lipidomics_negative | M1 |
| SA258153 | B1_3801_Lipidomics_negative | M1 |
| SA258154 | B1_3800_Lipidomics_negative | M1 |
| SA258155 | A1_7130_HILIC_negative | M1 |
| SA258156 | A1_7575_Lipidomics_positive | M1 |
| SA258157 | B1_3800_HILIC_positive | M1 |
| SA258158 | B1_3801_HILIC_positive | M1 |
| SA258159 | B1_3796_HILIC_positive | M1 |
| SA258160 | A1_7049_Lipidomics_positive | M1 |
| SA258161 | B1_3800_Lipidomics_positive | M1 |
| SA258162 | B1_3796_Lipidomics_positive | M1 |
| SA258163 | A1_7049_HILIC_positive | M1 |
| SA258164 | A1_7050_HILIC_positive | M1 |
| SA258165 | A1_7130_Lipidomics_positive | M1 |
| SA258166 | A1_7575_HILIC_negative | M1 |
| SA258167 | A1_7050_Lipidomics_positive | M1 |
| SA258168 | A1_7575_HILIC_positive | M1 |
| SA258169 | A1_7130_HILIC_positive | M1 |
| SA258170 | A1_7050_Lipidomics_negative | M1 |
| SA258171 | B2_7350_Lipidomics_positive | M2 |
| SA258172 | A2_7743_Lipidomics_positive | M2 |
| SA258173 | B2_7152_Lipidomics_positive | M2 |
| SA258174 | A2_6680_Lipidomics_positive | M2 |
| SA258175 | A2_7344_Lipidomics_positive | M2 |
| SA258176 | B2_7350_Lipidomics_negative | M2 |
| SA258177 | A2_7743_Lipidomics_negative | M2 |
| SA258178 | B2_7152_Lipidomics_negative | M2 |
| SA258179 | A2_7344_Lipidomics_negative | M2 |
| SA258180 | A2_6680_Lipidomics_negative | M2 |
| SA258181 | B2_7350_HILIC_negative | M2 |
| SA258182 | B2_7350_HILIC_positive | M2 |
| SA258183 | B2_7152_HILIC_negative | M2 |
| SA258184 | A2_7743_HILIC_negative | M2 |
| SA258185 | A2_6680_HILIC_positive | M2 |
| SA258186 | A2_7344_HILIC_negative | M2 |
| SA258187 | A2_7743_HILIC_positive | M2 |
| SA258188 | B2_7152_HILIC_positive | M2 |
| SA258189 | A2_7344_HILIC_positive | M2 |
| SA258190 | A2_6680_HILIC_negative | M2 |
| SA258191 | A2_6701_HILIC_negative | M3 |
| SA258192 | A2_6701_HILIC_positive | M3 |
| SA258193 | B3_2600_HILIC_positive | M3 |
| SA258194 | B3_5248_HILIC_positive | M3 |
