Summary of Study ST000888
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000617. The data can be accessed directly via it's Project DOI: 10.21228/M8X96N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000888 |
Study Title | Lyme Disease Biosignature Training (95 MFs) |
Study Type | Metabolomic Analysis |
Study Summary | Retrospective serum samples from patients with early Lyme disease, other diseases, and healthy controls were analyzed for small molecule metabolites by liquid chromatography-mass spectrometry (LC-MS). A metabolomics data workflow was applied to select a biosignature for classifying early Lyme disease and non-Lyme disease patients. A statistical model of the biosignature was trained using the patients' LC-MS data, and subsequently applied as an experimental diagnostic tool with LC-MS data from additional patient sera. |
Institute | Colorado State University |
Department | Department of Microbiology, Immunology, and Pathology |
Laboratory | Belisle |
Last Name | Belisle |
First Name | John |
Address | 200 West Lake, Campus Delivery 0922, Colorado State University, Fort Collins, CO, 80523, USA |
john.belisle@colostate.edu | |
Phone | 970-491-5384 |
Submit Date | 2017-09-05 |
Num Groups | 9 |
Study Comments | All samples and data used in training are provided. All samples and data used in testing are provided, except healthy controls that were experimentally heat treated. |
Publications | https://doi.org/10.1093/cid/civ185 |
Analysis Type Detail | LC-MS |
Release Date | 2017-11-15 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN001450 |
---|---|
Analysis type | MS |
Chromatography type | Reversed phase |
Chromatography system | Agilent 1200 |
Column | Poroshell 120,EC-C8(100 x 2.1mm,2.5um) |
MS Type | ESI |
MS instrument type | QTOF |
MS instrument name | Agilent 6520 QTOF |
Ion Mode | POSITIVE |
Units | peak area |
MS:
MS ID: | MS001340 |
Analysis ID: | AN001450 |
Instrument Name: | Agilent 6520 QTOF |
Instrument Type: | QTOF |
MS Type: | ESI |
Ion Mode: | POSITIVE |
Capillary Voltage: | 2000 V |
Dry Gas Flow: | 8 l/min |
Dry Gas Temp: | 300 |
Fragment Voltage: | 120 V |
Nebulizer: | 45 psi |
Octpole Voltage: | 750 V |
Scanning Cycle: | 666.7 spectra/s |
Scanning Range: | 115 - 1500 Da |
Skimmer Voltage: | 60 V |