Summary of Study ST000888
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000617. The data can be accessed directly via it's Project DOI: 10.21228/M8X96N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000888 |
| Study Title | Lyme Disease Biosignature Training (95 MFs) |
| Study Type | Metabolomic Analysis |
| Study Summary | Retrospective serum samples from patients with early Lyme disease, other diseases, and healthy controls were analyzed for small molecule metabolites by liquid chromatography-mass spectrometry (LC-MS). A metabolomics data workflow was applied to select a biosignature for classifying early Lyme disease and non-Lyme disease patients. A statistical model of the biosignature was trained using the patients' LC-MS data, and subsequently applied as an experimental diagnostic tool with LC-MS data from additional patient sera. |
| Institute | Colorado State University |
| Department | Department of Microbiology, Immunology, and Pathology |
| Laboratory | Belisle |
| Last Name | Belisle |
| First Name | John |
| Address | 200 West Lake, Campus Delivery 0922, Colorado State University, Fort Collins, CO, 80523, USA |
| john.belisle@colostate.edu | |
| Phone | 970-491-5384 |
| Submit Date | 2017-09-05 |
| Num Groups | 9 |
| Study Comments | All samples and data used in training are provided. All samples and data used in testing are provided, except healthy controls that were experimentally heat treated. |
| Publications | https://doi.org/10.1093/cid/civ185 |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-11-15 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR000617 |
| Project DOI: | doi: 10.21228/M8X96N |
| Project Title: | Development of a Metabolic Biosignature for Detection of Early Lyme Disease |
| Project Type: | MS Study |
| Project Summary: | Proof-of-concept studies for a LC-MS metabolite-based biosignature that classifies early Lyme disease patients from non-Lyme disease patients through metabolomics analyses of patient sera. |
| Institute: | Colorado State University |
| Department: | Department of Microbiology, Immunology, and Pathology |
| Laboratory: | Belisle |
| Last Name: | Belisle |
| First Name: | John |
| Address: | 200 West Lake, Campus Delivery 0922, Colorado State University, Fort Collins, CO, 80523, USA |
| Email: | john.belisle@colostate.edu |
| Phone: | 9704915384 |
| Funding Source: | NIAID/NIH/HHS AI100228 |
| Publications: | https://doi.org/10.1093/cid/civ185 |
