Summary of Study ST001666
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001070. The data can be accessed directly via it's Project DOI: 10.21228/M8D12Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001666 |
| Study Title | Branched-chain alpha-ketoacids are preferentially reaminated and activate protein synthesis in the mouse heart |
| Study Summary | Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that sequestration of BCAA and BCKA away from mitochondrial oxidation is likely due to low levels of expression of the mitochondrial BCAA transporter SLC25A44 in the heart, as its overexpression significantly lowers accumulation of [13C]-labeled valine from [U-13C]KIV. |
| Institute | Duke University |
| Last Name | Walejko |
| First Name | Jacquelyn |
| Address | 300 N Duke St |
| jacquelyn.walejko@duke.edu | |
| Phone | 9194792304 |
| Submit Date | 2021-01-26 |
| Analysis Type Detail | GC-MS |
| Release Date | 2021-02-09 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN002718 |
|---|---|
| Analysis type | MS |
| Chromatography type | GC |
| Chromatography system | Agilent 7890B |
| Column | Agilent HP5-MS (30m x 0.25mm, 0.25 um) |
| MS Type | EI |
| MS instrument type | Single quadrupole |
| MS instrument name | Agilent 5977A |
| Ion Mode | UNSPECIFIED |
| Units | Concentration of 13C (uM) |
MS:
| MS ID: | MS002515 |
| Analysis ID: | AN002718 |
| Instrument Name: | Agilent 5977A |
| Instrument Type: | Single quadrupole |
| MS Type: | EI |
| MS Comments: | Masshunter used for data acquisition and processing. |
| Ion Mode: | UNSPECIFIED |
