Summary of Study ST002294
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002294 |
Study Title | Metabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the polar metabolome of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer (part 1) |
Study Type | NMR-based metabolomics |
Study Summary | Platinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on polar metabolism of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer. |
Institute | University of Aveiro |
Department | Department of Chemistry and CICECO-Aveiro Institute of Materials |
Laboratory | Metabolomics from Ana M. Gil |
Last Name | Carneiro |
First Name | Tatiana João |
Address | Campus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal |
tatiana.joao@ua.pt | |
Phone | +351926369478 |
Submit Date | 2022-09-14 |
Num Groups | 3 |
Total Subjects | 22 |
Num Females | 22 |
Raw Data Available | Yes |
Raw Data File Type(s) | fid |
Analysis Type Detail | NMR |
Release Date | 2022-12-15 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
NMR:
NMR ID: | NM000251 |
Analysis ID: | AN003748 |
Instrument Name: | Avance III TM HD 500MHz |
Instrument Type: | FT-NMR |
NMR Experiment Type: | 1D-1H |
NMR Comments: | 1st subfolder contains raw spectra; 2nd subfolder contains manually processed spectra |
Field Frequency Lock: | Deuterium |
Spectrometer Frequency: | 500MHz |
NMR Probe: | TXI |
NMR Solvent: | D2O |
NMR Tube Size: | 5mm |
Shimming Method: | Topshim |
Receiver Gain: | 203 |
Temperature: | 298K |
Number Of Scans: | 512 |
Acquisition Time: | 2.34s |
Relaxation Delay: | 2s |
Spectral Width: | 7002.801 |
Zero Filling: | 64k |
Baseline Correction Method: | Manual |
Chemical Shift Ref Std: | TSP (3-(trimethylsilyl)-propionic-2,2,3,3-d4 acid) |
NMR Results File: | LiverAE_NMR_data.txt UNITS:ppm |