Summary of Study ST002294
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002294 |
Study Title | Metabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the polar metabolome of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer (part 1) |
Study Type | NMR-based metabolomics |
Study Summary | Platinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on polar metabolism of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer. |
Institute | University of Aveiro |
Department | Department of Chemistry and CICECO-Aveiro Institute of Materials |
Laboratory | Metabolomics from Ana M. Gil |
Last Name | Carneiro |
First Name | Tatiana João |
Address | Campus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal |
tatiana.joao@ua.pt | |
Phone | +351926369478 |
Submit Date | 2022-09-14 |
Num Groups | 3 |
Total Subjects | 22 |
Num Females | 22 |
Raw Data Available | Yes |
Raw Data File Type(s) | fid |
Analysis Type Detail | NMR |
Release Date | 2022-12-15 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Subject:
Subject ID: | SU002380 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
Genotype Strain: | CBA nude (N:NIH(S)II-nu/nu) |
Age Or Age Range: | 6 to 7-weeks old |
Gender: | Female |
Animal Animal Supplier: | i3S Animal Facility (Porto, Portugal) |
Animal Housing: | ICBAS-UP Rodent Animal House Facility (Porto, Portugal) |
Animal Light Cycle: | 12h light/dark cycles (7.00 AM lights on) |
Animal Feed: | ad libitum |
Animal Water: | ad libitum |
Animal Inclusion Criteria: | Healthy animails |
Species Group: | CBA nude (N:NIH(S)II-nu/nu) |