Summary of Study ST000074
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000071. The data can be accessed directly via it's Project DOI: 10.21228/M8G01M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000074 |
| Study Title | Genetic effects of high fat diet on mouse fecal metabolomics |
| Study Summary | This study includes 72 female mice with 4 mice from each of the 18 mice strains. Two mice from each strain were fed a high fat diet and two mice were fed a normal fat diet. The 36 mice fed a normal fat diet will serve as the controls. All mice are age 27.6 weeks or older at the time of sacrifice. UPLC-MS data was collected for all 72 samples. |
| Institute | University of North Carolina |
| Department | Discovery and Analytical Sciences (DAS) |
| Laboratory | Sumner Lab |
| Last Name | Sumner |
| First Name | Susan |
| Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
| susan_sumner @unc.edu | |
| Phone | 704-250-5066 |
| Submit Date | 2014-06-14 |
| Num Groups | 36 |
| Total Subjects | 72 |
| Raw Data Available | No |
| Raw Data File Type(s) | raw(Waters) |
| Analysis Type Detail | LC-MS |
| Release Date | 2015-06-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR000071 |
| Project DOI: | doi: 10.21228/M8G01M |
| Project Title: | Genetic effects of high fat diet on mouse fecal metabolomics |
| Project Type: | Analysis of fecal metabolite profiles of genetically diverse BXD mouse strains receiving diets high or low in fat to elucidate the metabolism of the GI tract and obesity |
| Project Summary: | We will study expression of a large series of metabolites in fecal samples from a genetically diverse set of mouse strains (BXD type). Separate cohorts of animals are maintained either on a 6% low fat diet or on a 60% high fat diet and at several points during normal life span. We predict that these dietary differences will have profound effects on the gastrointestinal (GI) tract and fecal metabolites, and that the differences will be influenced strongly by genetic factors. We also expect that fecal metabolite data will be a useful predictor of major outcome measures, such as fat mass, longevity, and mitochondrial state. All metabolite data will be entered into the GeneNetwork web service for genetic analysis of the effects of metabolites and diet on GI tract metabolism. |
| Institute: | University of Tennessee |
| Department: | Department of Anatomy and Neurobiology, Health Science Center |
| Last Name: | Williams |
| First Name: | Rovert |
| Address: | 855 Monroe Avenue, #515 LINK bldg, Memphis TN 38163 USA |
| Email: | rwilliams@uthsc.edu |
| Phone: | 901-448-7050 |
