Summary of Study ST000134

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000119. The data can be accessed directly via it's Project DOI: 10.21228/M86C76 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000134
Study TitleMonitoring In Vitro Response of Selenium-Treated Prostate Cells by 1H NMR Spectroscopy
Study TypeMetabolite level response after treatment with organoselenium
Study SummaryMetabolomics analysis was performed on DU145 prostate cancer cells and PNT1A non-tumorigenic prostate cells after treatment with selenomethionine and Se-methylselenocysteine using 800 MHz Bruker NMR spectrometer on 18 cell samples.
Purdue University
Last NameIsaac-Lam
First NameMeden
Address1401 S US Hwy 421, Westville, IN 46391
Submit Date2015-01-13
Num Groups6
Total Subjects18
Raw Data AvailableNo
Analysis Type DetailNMR
Release Date2015-01-13
Release Version1
Meden Isaac-Lam Meden Isaac-Lam application/zip

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Project ID:PR000119
Project DOI:doi: 10.21228/M86C76
Project Title:Monitoring In Vitro Response of Selenium-Treated Prostate Cells by 1H NMR Spectroscopy
Project Type:Metabolomics by 1H NMR
Project Summary:1H NMR data of prostate cells treated with selenium showed a decreasing trend in metabolite levels with the largest change exhibited by creatine mainly due to disrupted energy metabolism, and probably due to loss of structural integrity combined with external dissipation of metabolites. Lactate, choline-containing compounds, and glycine levels increased depending on the type of selenium used and the cell type. Principal component analysis (PCA) showed that SeM-treated cells can be distinguished from SeMSC-treated cells, and DU145 PCa from PNT1A normal cells.
Institute:Purdue University
Laboratory:Biology/Chemistry Dept
Last Name:Isaac-Lam
First Name:Meden
Address:1401 S US Hwy 421 Westville, Indiana USA
Funding Source:Indiana Academy of Science