Summary of Study ST000361
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000287. The data can be accessed directly via it's Project DOI: 10.21228/M8Z310 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000361 |
Study Title | Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder |
Study Type | Broad Spectrum LCMS |
Study Summary | Patients with Bipolar I Disorder (BPI) and matched non-affected controls were recruited. Males and females from all races and ethnicities between the ages of 19-65 participated in the research. Skin biopsies were obtained and fibroblasts were isolated from each of these biopsies. A total of 1 x 〖10〗^7 fibroblasts cells were used for metabolomics. Cell pellets were flash frozen in liquid nitrogen and shipped on dry ice to the NIH Eastern Regional Comprehensive Metabolomic Resource Core at RTI International in North Carolina. Metabolomics will be determined using a broad spectrum metabolomics protocol by RTI |
Institute | University of North Carolina |
Department | Discovery Sciences |
Laboratory | Sumner Lab |
Last Name | Sumner |
First Name | Susan |
Address | Eastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081 |
susan_sumner @unc.edu | |
Phone | 704-250-5066 |
Submit Date | 2016-03-05 |
Num Groups | 2 |
Total Subjects | 18 |
Num Males | 7 |
Num Females | 11 |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Waters) |
Analysis Type Detail | LC-MS |
Release Date | 2017-03-03 |
Release Version | 1 |
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Project:
Project ID: | PR000287 |
Project DOI: | doi: 10.21228/M8Z310 |
Project Title: | Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder |
Project Type: | Broad Spectrum LCMS |
Project Summary: | Bipolar disorder is a serious condition characterized by severe and debilitating elevations and depressions in mood and energy (1). Bipolar I disorder (BPI) is a particularly severe phenotype which is generally defined as having periods of abnormal moods ranging from “highs,” (mania or hypomania), to “lows” (depression), alternating with periods of relatively normal moods. Key problems in treating bipolar disorder relate to the fact that the pathophysiology of the disorder remains elusive; as a result, there are currently no laboratory tests for diagnosis, to aid treatment decisions, or to predict treatment responses. Recent advances in the study of bipolar disorder increasingly implicate mitochondrial and bioenergetic dysfunction as a common feature of the pathophysiology of the disorder (2). Shifts in metabolism from mitochondrial oxidative phosphorylation toward glycolysis have been observed in the brains of bipolar patients experiencing depressive mood states (3). Increased oxidative stress has also been shown in postmortem brain from bipolar patients (4), and in cultured peripheral fibroblasts from patients with major depression (5). However, little is known about the inherent metabolic state of peripheral cells during bipolar disorder, which may reflect the overall metabolic profile of the individual and may also impact the supply of nutrients to the brain. We propose to characterize the baseline metabolomic profiles of peripheral cells in cultured fibroblasts from patients with BPI and matched non-affected controls. Patients with Bipolar I Disorder (BPI) and matched non-affected controls were recruited. Males and females from all races and ethnicities between the ages of 19-65 participated in the research. Skin biopsies were obtained and fibroblasts were isolated from each of these biopsies. A total of 1 x 〖10〗^7 fibroblasts cells were used for metabolomics. Cell pellets were flash frozen in liquid nitrogen and shipped on dry ice to the NIH Eastern Regional Comprehensive Metabolomic Resource Core at RTI International in North Carolina. Metabolomics will be determined using a broad spectrum metabolomics protocol by RTI. |
Institute: | University of Alabama, Birmingham |
Department: | School of Medicine |
Laboratory: | Department of Pathology |
Last Name: | Landar |
First Name: | Aimee |
Address: | BMR2 506 901 9th St South, Birmingham AL 35205 |
Email: | landar@uab.edu |
Phone: | 205-975-9507 |
Funding Source: | NIH, Common Fund, Pilot and Feasibility |