Summary of Study ST000565
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000415. The data can be accessed directly via it's Project DOI: 10.21228/M8DK6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000565 |
| Study Title | Association of hemodialysis patient plasma trace metals with response to erythropoiesis stimulating agents |
| Study Type | Metallomics |
| Study Summary | EDTA-Plasma from 110 hemodialysis patients participating in an NIDDK funded study were analyzed by ICP-MS for the concentration of As, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Sn, V, and Zn. Associations were determined between trace metals and gender, race, hemodialysis status, hemoglobin at the time of draw (Hgb), total ESA dose for the month the sample was collected (EPO), and erythropoietin resistance index determined over the 6 months of treatment leading up to sample collection (ERI) |
| Institute | RTI International |
| Laboratory | NIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC) |
| Last Name | Sumner |
| First Name | Susan |
| Address | 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA |
| susan_sumner@unc.edu | |
| Phone | 704-250-5000 |
| Submit Date | 2017-02-27 |
| Total Subjects | 110 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | dat |
| Analysis Type Detail | ICP-MS |
| Release Date | 2018-08-27 |
| Release Version | 1 |
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Project:
| Project ID: | PR000415 |
| Project DOI: | doi: 10.21228/M8DK6R |
| Project Title: | Association of hemodialysis patient plasma trace metals with response to erythropoiesis stimulating agents |
| Project Type: | Metallomics |
| Project Summary: | Erythropoietin (EPO) is a cytokine used to treat the anemia of chronic renal disease in greater than 90% of all in-center hemodialysis patients at a cost of approximately 2 billion dollars per year (2010). Despite protocols for anemia management in the end stage kidney disease (ESKD) population, a large proportion of patients do not predictably respond to typical doses of EPO. Several recent randomized controlled trials looking to increase hemoglobin in patients with the anemia of renal disease have uncovered many questions about the treatment of anemia with erythropoietic stimulating agents (ESA) not previously addressed in new drug applications or in subsequent research. We sought to test the hypothesis that serum trace metal concentrations correlate with markers of anemia and response to ESA treatment. EDTA-Plasma from 110 hemodialysis patients participating in an NIDDK funded study (R01-01DK091584) were analyzed by ICP-MS for the concentration of As, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Sn, V, and Zn. Associations were determined between trace metals and gender, race, hemodialysis status, hemoglobin at the time of draw (Hgb), total ESA dose for the month the sample was collected (EPO), and erythropoietin resistance index determined over the 6 months of treatment leading up to sample collection (ERI). |
| Institute: | University of Louisville |
| Department: | School of Medicine, Division of Nephrology & Hypertension |
| Last Name: | Merchant |
| First Name: | Michael |
| Address: | 550 South Jackson Street, 3rd Floor, Louisville, Kentucky 40202 |
| Email: | michael.merchant@louisville.edu |
| Phone: | 502/852-0245 |
| Funding Source: | NIH Grants 1R01DK091584, U24DK097193, and K01GM109320 |
