Summary of Study ST000565
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000415. The data can be accessed directly via it's Project DOI: 10.21228/M8DK6R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000565 |
| Study Title | Association of hemodialysis patient plasma trace metals with response to erythropoiesis stimulating agents |
| Study Type | Metallomics |
| Study Summary | EDTA-Plasma from 110 hemodialysis patients participating in an NIDDK funded study were analyzed by ICP-MS for the concentration of As, Cd, Co, Cr, Cu, Mn, Mo, Ni, Pb, Sb, Se, Sn, V, and Zn. Associations were determined between trace metals and gender, race, hemodialysis status, hemoglobin at the time of draw (Hgb), total ESA dose for the month the sample was collected (EPO), and erythropoietin resistance index determined over the 6 months of treatment leading up to sample collection (ERI) |
| Institute | RTI International |
| Laboratory | NIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC) |
| Last Name | Sumner |
| First Name | Susan |
| Address | 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA |
| susan_sumner@unc.edu | |
| Phone | 704-250-5000 |
| Submit Date | 2017-02-27 |
| Total Subjects | 110 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | dat |
| Analysis Type Detail | ICP-MS |
| Release Date | 2018-08-27 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP000594 |
| Sampleprep Summary: | A volume of 150 µL of each EDTA-plasma sample was dispensed into an acid-washed plastic digestion tube. To each digestion vessel, 300 µL of concentrated HNO3, 150 µL of concentrated HCl, and 100 µL of H2O2 solution was added. Samples were loosely capped and placed in the graphite digestion block and heated at a temperature of 90 °C for 2 hours. At the end of digestion, all samples were removed from the heating block and allowed to cool to room temperature. In the clean hood, samples were spiked with a multielement internal standard to provide a final concentration of 1.0 ng/mL Sc, In, and Pr, and diluted to the final volume with deionized (DI) H2O. |
| Processing Method: | Acid Digestion |
| Processing Storage Conditions: | 90°C |
| Extract Storage: | 8°C |
| Sample Spiking: | Sc, In, Pr |
