Summary of Study ST001379
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000916. The data can be accessed directly via it's Project DOI: 10.21228/M8912S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001379 |
| Study Title | 2,3,7,8 -Tetrachlorodibenzo-p-dioxin Mediated Effects on Hepatic Coenzyme A (CoA) and Acetyl-CoA Levels (part-II) |
| Study Type | Dioxin |
| Study Summary | Experiment to study TCDD-elicited effects on hepatic Coenzyme A (CoA) and Acetyl-CoA levels in liver of male mice treated with sesame oil vehicle or 0.01-30 ug/kg TCDD every 4 days for 28 days. |
| Institute | Michigan State University |
| Department | Biochemistry and Molecular Biology |
| Laboratory | Zacharewski Lab |
| Last Name | Fling |
| First Name | Russell |
| Address | 1129 Farm Ln, East Lansing, MI, USA |
| flingrus@msu.edu | |
| Phone | (517) 884-2054 |
| Submit Date | 2020-04-01 |
| Num Groups | 9 |
| Total Subjects | 80 |
| Num Males | 29 |
| Study Comments | Fax: (517) 353-9334; ORCID: 0000-0002-6822-4962; ROLE: Graduate Student; Pubmed ID: -;Publication DOI: -; |
| Publications | - |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Waters) |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-08-02 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Treatment:
| Treatment ID: | TR001468 |
| Treatment Summary: | oral gavage every 4 days for 28 days. 7 total exposures with sesame oil vehicle or 0.3-30 ug/kg TCDD. |
| Treatment Protocol Comments: | Administration Interval: 4; Administration Interval Unit: DAYS; Dose Unit: ug/kg; Number of Administrations: 7; Chemical Soucre: AccuStandard; Chemical Catalog Number: S-70982; Chemical Purity: -; Vehicle Substance: CHEBI 28119 |
| Treatment Compound: | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
| Treatment Route: | GAVAGE |
| Treatment Dose: | 0.3,1,3,10,30 |
| Treatment Dosevolume: | 0.1 ml |
| Treatment Vehicle: | Sesame oil |
| Animal Fasting: | 2 hrs before end-point |
| Animal Endp Euthanasia: | CO2 |
