Summary of Study ST001871
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001181. The data can be accessed directly via it's Project DOI: 10.21228/M82418 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001871 |
Study Title | Untargeted LC-MS metabolomics analysis of cecal content of mice treated with TCDD vs. vehicle control (part I) |
Study Type | Untargeted metabolomics |
Study Summary | Six-week-old female wildtype (WT) C57BL/6 mice were administered a single 100µl intraperitoneal injection containing sterile corn oil (VEH group) or an intraperitoneal injection of 10µg/kg TCDD suspended within sterile corn oil (TCDD group). At the 72h time point following TCDD or VEH exposure, the mice were humanely euthanized by an overdose of inhaled isoflurane. During necropsy, cecal content and blood serum samples were collected for untargeted metabolomics profiling. |
Institute | University of South Carolina School of Medicine |
Department | Department of Pathology |
Laboratory | (On behalf of) Mitzi Nagarkatti Lab |
Last Name | Lai |
First Name | Yunjia |
Address | 135 Dauer Drive, Chapel Hill, NC 27599 |
yunjia.lai@outlook.com | |
Phone | 919-480-5489 |
Submit Date | 2021-07-16 |
Num Groups | 2 |
Total Subjects | 20 |
Num Females | 20 |
Publications | Chemosphere |
Raw Data Available | Yes |
Raw Data File Type(s) | raw(Thermo) |
Analysis Type Detail | LC-MS |
Release Date | 2021-08-30 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001960 |
Treatment Summary: | Six-week-old female wildtype (WT) C57BL/6 mice acquired from Jackson Laboratories (Bar Harbor, ME) were housed in an AAALAC-accredited specific-pathogen-free animal facility located at the grounds of the University of South Carolina School of Medicine for the entirety of all experiments. Mice within the facility were housed within polycarbonate cages containing cellulose fiber chips as bedding in a temperature and humidity-controlled environment. After a 2-week acclimatization period, the mice were divided randomly into two groups that would be administered a single 100µl intraperitoneal injection containing sterile corn oil (VEH group) or an intraperitoneal injection of 10µg/kg TCDD suspended within sterile corn oil (TCDD group). At the 72h time point following TCDD or VEH exposure, the mice were humanely euthanized by an overdose of inhaled isoflurane. Cecal content and blood sera were collected at the time of necropsy. |