Summary of study ST000056

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000053. The data can be accessed directly via it's Project DOI: 10.21228/M8C883 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000056
Study TitleEnvironmental impact on metabolomics and food allergy
Study TypeMetabolomics
Study SummaryThis metabolomics pilot and feasibility (P&F) was conducted to determine if varying the levels of environmental LPS exposure and immunization with the vaccine adjuvant alum alters host metabolism. Additionally, the metabolomics will identify biomarkers that can predict allergic disease development and or disease severity after a peanut challenge in hypersensitive mice. Information gained from the proposed studies may allow for the identification of individuals who are “at risk” or “not at risk” for the development of allergic disease. Furthermore, completion of these studies may lead to identification of biological targets that may be used to develop novel therapies to treat or prevent allergic disease via future funding.
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Submit Date2014-05-31
Num Groups2
Raw Data AvailableYes
Raw Data File Type(s)binary files in pdata
Uploaded File Size68 M
Analysis Type DetailNMR
Release Date2015-06-01
Release Version1
Susan Sumner Susan Sumner application/zip

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Project ID:PR000053
Project DOI:doi: 10.21228/M8C883
Project Title:Environmental impact on metabolomics and food allergy
Project Type:food allergy vaccine development
Project Summary:NIH R03 grant to develop a mouse model that evaluates the cumulative effect of reduced LPS exposure and vaccination with alum-adjuvanted vaccines on the development and severity of peanut allergy.
Institute:Duke University
Department:Medical Center
Last Name:Staats
First Name:Herman