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MGP000015

Record overview

MGPD IDMGP000015
Gene ID30
SpeciesHomo sapiens (Human)
Gene Nameacetyl-CoA acyltransferase 1
Gene Symbol ACAA1
SynonymsACAA; THIO; PTHIO;
Alternate names3-ketoacyl-CoA thiolase, peroxisomal; acetyl-Coenzyme A acyltransferase 1; beta-ketothiolase; peroxisomal 3-oxoacyl-CoA thiolase; peroxisomal 3-oxoacyl-Coenzyme A thiolase;
Chromosome3
Map Location3p22.2
EC Number2.3.1.16
SummaryThis gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ACAA1

Proteins

3-ketoacyl-CoA thiolase, peroxisomal isoform a
Refseq ID:NP_001598
Protein GI:4501853
UniProt ID:P09110
mRNA ID:NM_001607
Length:424
RefSeq Status:
MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIM
ARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQD
TFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPI
LGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKR
AYGVVSMCIGTGMGAAAVFEYPGN
 
transit_peptide: 1..26
experiment: experimental evidence, no additional details recorded
note: Peroxisome; propagated from UniProtKB/Swiss-Prot (P09110.2)
calculated_mol_wt: 2819
peptide sequence: 
MQRLQVVLGHLRGPADSGWMPQAAPC

mat_peptide: 27..424
product: 3-ketoacyl-CoA thiolase, peroxisomal
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P09110.2)
calculated_mol_wt: 41491
peptide sequence: 
LSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSG
LQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPV
TTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIP
VALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
 
3-ketoacyl-CoA thiolase, peroxisomal isoform b
Refseq ID:NP_001123882
Protein GI:194353979
UniProt ID:P09110
mRNA ID:NM_001130410
Length:331
RefSeq Status:
MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIM
ARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDD
KGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNE
LKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
 
transit_peptide: 1..26
experiment: experimental evidence, no additional details recorded
note: Peroxisome; propagated from UniProtKB/Swiss-Prot (P09110.2)
calculated_mol_wt: 2819
peptide sequence: 
MQRLQVVLGHLRGPADSGWMPQAAPC

mat_peptide: 27..424
product: 3-ketoacyl-CoA thiolase, peroxisomal
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P09110.2)
calculated_mol_wt: 41491
peptide sequence: 
LSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSG
LQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPV
TTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIP
VALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
 
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