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MGP000015

UniProt Annotations

Entry Information
Gene Nameacetyl-CoA acyltransferase 1
Protein EntryTHIK_HUMAN
UniProt IDP09110
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09110-1; Sequence=Displayed; Name=2; IsoId=P09110-2; Sequence=VSP_046195, VSP_046196; Note=No experimental confirmation available.;
Catalytic ActivityAcyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
InductionPeroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.
PathwayLipid metabolism; fatty acid metabolism.
SimilarityBelongs to the thiolase family. {ECO:0000305}.
Subcellular LocationPeroxisome.
SubunitHomodimer. {ECO:0000269|Ref.10}.
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