MGP Database

MGP000018

Record overview

MGPD ID	MGP000018
Gene ID	33
Species	Homo sapiens (Human)
Gene Name	acyl-CoA dehydrogenase, long chain
Gene Symbol	ACADL
Synonyms	LCAD; ACAD4;
Alternate names	long-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, long chain;
Chromosome	2
Map Location	2q34
EC Number	1.3.8.8
Summary	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for ACADL

Proteins

long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Refseq ID:	NP_001599
Protein GI:	4501857
UniProt ID:	P28330
mRNA ID:	NM_001608
Length:	430
RefSeq Status:

MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLG
VNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGS
KVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAK
AYVDARVQPIYGGTNEIMKELIAREIVFDK

transit_peptide: 1..30
calculated_mol_wt: 3239
peptide sequence: 
MAARLLRGSLRVLGGHRAPRQLPAARCSHS

mat_peptide: 31..430
product: long-chain specific acyl-CoA dehydrogenase, mitochondrial
calculated_mol_wt: 44435
peptide sequence: 
GGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCS
GPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGI
SLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTV
QHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK