MGP Database

MGP000027

Record overview

MGPD ID	MGP000027
Gene ID	43
Species	Homo sapiens (Human)
Gene Name	acetylcholinesterase (Yt blood group)
Gene Symbol	ACHE
Synonyms	YT; ACEE; ARACHE; N-ACHE;
Alternate names	acetylcholinesterase; Yt blood group; apoptosis-related acetylcholinesterase;
Chromosome	7
Map Location	7q22
EC Number	3.1.1.7
Summary	Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for ACHE

Proteins

acetylcholinesterase isoform 3 precursor

Refseq ID:	NP_001269378
Protein GI:	540344531
UniProt ID:	P22303
mRNA ID:	NM_001282449
Length:	526
RefSeq Status:

MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVC
YQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG
NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGI
PLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEF
HRWSSYMVHWKNQFDHYSKQDRCSDL

sig_peptide: 1..31
calculated_mol_wt: 3238
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGA

mat_peptide: 32..588
product: acetylcholinesterase isoform E4-E5
calculated_mol_wt: 60863
peptide sequence: 
EGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN
VWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLF
GESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV
PVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSD
VVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQW
PPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

acetylcholinesterase isoform E4-E5 precursor

Refseq ID:	NP_001289550
Protein GI:	705044464
UniProt ID:
mRNA ID:	NM_001302621
Length:	617
RefSeq Status:

MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVC
YQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG
NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQ
VSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEE
KIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHGEAAPRPGLPLPL
LLLHQLLLLFLSHLRRL

sig_peptide: 1..31
calculated_mol_wt: 3238
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGA

mat_peptide: 32..588
product: acetylcholinesterase isoform E4-E5
calculated_mol_wt: 60863
peptide sequence: 
EGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN
VWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLF
GESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV
PVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSD
VVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQW
PPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

acetylcholinesterase isoform E4-E5 precursor

Refseq ID:	NP_056646
Protein GI:	7710112
UniProt ID:	P22303
mRNA ID:	NM_015831
Length:	617
RefSeq Status:

Protein sequence is identical to GI:705044464 (mRNA isoform)

sig_peptide: 1..31
calculated_mol_wt: 3238
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGA

mat_peptide: 32..588
product: acetylcholinesterase isoform E4-E5
calculated_mol_wt: 60863
peptide sequence: 
EGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN
VWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLF
GESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV
PVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSD
VVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQW
PPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHG

acetylcholinesterase isoform E4-E6 precursor

Refseq ID:	NP_000656
Protein GI:	4557239
UniProt ID:	P22303
mRNA ID:	NM_000665
Length:	614
RefSeq Status:

MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVC
YQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG
NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQ
VSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEE
KIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

sig_peptide: 1..31
calculated_mol_wt: 3238
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGA

mat_peptide: 32..588
product: acetylcholinesterase isoform E4-E5
calculated_mol_wt: 60863
peptide sequence: 
EGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN
VWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLF
GESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV
PVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSD
VVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQW
PPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

acetylcholinesterase isoform E4-E6 precursor

Refseq ID:	NP_001289551
Protein GI:	705044511
UniProt ID:
mRNA ID:	NM_001302622
Length:	614
RefSeq Status:

Protein sequence is identical to GI:4557239 (mRNA isoform)

sig_peptide: 1..31
calculated_mol_wt: 3238
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGA

mat_peptide: 32..588
product: acetylcholinesterase isoform E4-E5
calculated_mol_wt: 60863
peptide sequence: 
EGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN
VWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLF
GESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV
PVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSD
VVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQW
PPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATASEAPSTCPGFTHG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG

sig_peptide: 1..33
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3424
peptide sequence: 
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEG