MGP Database

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MGP000056

Ontology/Pathway Information

Entrez Gene ID108
Gene Nameadenylate cyclase 2 (brain)
Gene Symbol ADCY2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0030425 ISS:UniProtKBCdendrite
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005622 ISS:BHF-UCLCintracellular
GO:0016020 ISS:UniProtKBCmembrane
GO:0045121 ISS:BHF-UCLCmembrane raft
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043234 IEA:EnsemblCprotein complex
GO:0004016 NAS:UniProtKBFadenylate cyclase activity
GO:0008179 ISS:BHF-UCLFadenylate cyclase binding
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008294 IEA:EnsemblFcalcium- and calmodulin-responsive adenylate cyclase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0046982 ISS:BHF-UCLFprotein heterodimerization activity
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0034199 TAS:ReactomePactivation of protein kinase A activity
GO:0007189 TAS:ReactomePadenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 TAS:ReactomePadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007188 ISS:BHF-UCLPadenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0006171 ISS:BHF-UCLPcAMP biosynthetic process
GO:0071377 TAS:ReactomePcellular response to glucagon stimulus
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 IEA:InterProPintracellular signal transduction
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0006833 TAS:ReactomePwater transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25330Activation of GABAB receptors
REACT_15312Adenylate cyclase activating pathway
REACT_15333Adenylate cyclase inhibitory pathway
REACT_23887Aquaporin-mediated transport
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_25031GABA B receptor activation
REACT_25199GABA receptor activation
REACT_19231G alpha (i) signalling events
REACT_19327G alpha (s) signalling events
REACT_19333G alpha (z) signalling events
REACT_1665Glucagon signaling in metabolic regulation
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_268323Hedgehog 'off' state
REACT_6900Immune System
REACT_25282Inhibition of adenylate cyclase pathway
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_15530PKA activation
REACT_1946PKA activation in glucagon signalling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_264508Signaling by Hedgehog
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_24023Vasopressin regulates renal water homeostasis via Aquaporins
SMP Pathway Links
SMP IDDescription
SMP00310Corticotropin Activation of Cortisol Production
SMP00308Dopamine Activation of Neurological Reward System
SMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
SMP00343Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
SMP00354Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
SMP00322Vasopressin Regulation of Water Homeostasis
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