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MGP000056

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 2 (brain)
Protein EntryADCY2_HUMAN
UniProt IDQ08462
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08462-1; Sequence=Displayed; Name=2; IsoId=Q08462-2; Sequence=VSP_055811, VSP_055812; Note=No experimental confirmation available.;
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Enzyme RegulationInsensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation. {ECO:0000250, ECO:0000269|PubMed:15385642}.
FunctionThis is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
PtmPhosphorylated by RAF1. {ECO:0000269|PubMed:15385642}.
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts with RAF1. {ECO:0000269|PubMed:15385642}.
Tissue SpecificityExpressed in brain.
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