MGP Database

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MGP000061

Ontology/Pathway Information

Entrez Gene ID114
Gene Nameadenylate cyclase 8 (brain)
Gene Symbol ADCY8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016020 TAS:ProtIncCmembrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004016 TAS:ProtIncFadenylate cyclase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008294 TAS:ProtIncFcalcium- and calmodulin-responsive adenylate cyclase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0034199 TAS:ReactomePactivation of protein kinase A activity
GO:0007189 TAS:ReactomePadenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 TAS:ReactomePadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0071377 TAS:ReactomePcellular response to glucagon stimulus
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 IEA:InterProPintracellular signal transduction
GO:0007611 TAS:ProtIncPlearning or memory
GO:0007616 IEA:EnsemblPlong-term memory
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0006833 TAS:ReactomePwater transport
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_25330Activation of GABAB receptors
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_15312Adenylate cyclase activating pathway
REACT_15333Adenylate cyclase inhibitory pathway
REACT_23887Aquaporin-mediated transport
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_20625CREB phosphorylation through the activation of Adenylate Cyclase
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_25031GABA B receptor activation
REACT_25199GABA receptor activation
REACT_19231G alpha (i) signalling events
REACT_19327G alpha (s) signalling events
REACT_19333G alpha (z) signalling events
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_1665Glucagon signaling in metabolic regulation
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_268323Hedgehog 'off' state
REACT_6900Immune System
REACT_25282Inhibition of adenylate cyclase pathway
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_21310Phospholipase C-mediated cascade
REACT_15530PKA activation
REACT_1946PKA activation in glucagon signalling
REACT_15497PKA-mediated phosphorylation of CREB
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_20593Post NMDA receptor activation events
REACT_18325Regulation of insulin secretion
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_264508Signaling by Hedgehog
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_24023Vasopressin regulates renal water homeostasis via Aquaporins
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