MGP Database

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MGP000061

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 8 (brain)
Protein EntryADCY8_HUMAN
UniProt IDP40145
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Enzyme RegulationActivated by calcium/calmodulin.
FunctionThis is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity). {ECO:0000250}.
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationMembrane; Multi-pass membrane protein.
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