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MGP000067

Record overview

MGPD IDMGP000067
Gene ID125
SpeciesHomo sapiens (Human)
Gene Namealcohol dehydrogenase 1B (class I), beta polypeptide
Gene Symbol ADH1B
SynonymsADH2; HEL-S-117;
Alternate namesalcohol dehydrogenase 1B; ADH, beta subunit; aldehyde reductase; alcohol dehydrogenase subunit beta; epididymis secretory protein Li 117; alcohol dehydrogenase 2 (class I), beta polypeptide;
Chromosome4
Map Location4q23
EC Number1.1.1.1
SummaryThe protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
OrthologsView orthologs and multiple alignments for ADH1B

Proteins

alcohol dehydrogenase 1B isoform 1
Refseq ID:NP_000659
Protein GI:34577061
UniProt ID:P00325
mRNA ID:NM_000668
Length:375
RefSeq Status:
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGK
CRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFG
LGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ
NLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
 
alcohol dehydrogenase 1B isoform 2
Refseq ID:NP_001273579
Protein GI:557786227
UniProt ID:P00325
mRNA ID:NM_001286650
Length:335
RefSeq Status:
MVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHH
FLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATE
CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKK
FSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
 
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