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MGP000067

UniProt Annotations

Entry Information
Gene Namealcohol dehydrogenase 1B (class I), beta polypeptide
Protein EntryADH1B_HUMAN
UniProt IDP00325
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P00325-1; Sequence=Displayed; Name=2; IsoId=P00325-2; Sequence=VSP_054847;
Catalytic ActivityAn alcohol + NAD(+) = an aldehyde or ketone + NADH.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
MiscellaneousThere are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6.
PolymorphismThree alleles are known: ADH1B*1 (ADH2*1) corresponding to variant beta-1, ADH1B*2 (ADH2*2) corresponding to variant beta-2, ADH1B*3 (ADH2*3) corresponding to variant beta-3. The sequence shown is that of allele ADH1B*1. The ADH1B*2 allele frequency in orientals is approximately 75%, whereas it is less than 5% in most Caucasian populations. ADH1B variations have been associated with protection against alcohol dependence and alcohol- related aerodigestive tract cancer [MIM:103720].
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitDimer of identical or non-identical chains of three types; alpha, beta and gamma.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh1b/";
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