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MGP000068

UniProt Annotations

Entry Information
Gene Namealcohol dehydrogenase 1C (class I), gamma polypeptide
Protein EntryADH1G_HUMAN
UniProt IDP00326
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn alcohol + NAD(+) = an aldehyde or ketone + NADH.
CautionThe reference genome assembly, GRCh37, describes a non- functional copy of that gene with a stop codon at position 78. However, this premature stop codon is not present in available mRNAs. {ECO:0000305}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
MiscellaneousThere are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6.
PolymorphismTwo main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate.
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitDimer of identical or non-identical chains of three types; alpha, beta and gamma. {ECO:0000269|PubMed:11274460, ECO:0000269|PubMed:15449945}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh1c/";
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