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MGP000071

Record overview

MGPD IDMGP000071
Gene ID131
SpeciesHomo sapiens (Human)
Gene Namealcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol ADH7
SynonymsADH4;
Alternate namesalcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase VII; alcohol dehydrogenase class IV mu/sigma chain; alcohol dehydrogenase-7; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase; gastric alcohol dehydrogenase; retinol dehydrogenase;
Chromosome4
Map Location4q23-q24
EC Number1.1.1.1
SummaryThis gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for ADH7

Proteins

alcohol dehydrogenase class 4 mu/sigma chain isoform 1
Refseq ID:NP_001159976
Protein GI:262073058
UniProt ID:P40394
mRNA ID:NM_001166504
Length:394
RefSeq Status:
MKCLVSRHTVRETLDMVFQRMSVEAGVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEG
VTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGY
GAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALA
SCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
 
alcohol dehydrogenase class 4 mu/sigma chain isoform 2
Refseq ID:NP_000664
Protein GI:71743840
UniProt ID:P40394
mRNA ID:NM_000673
Length:386
RefSeq Status:
MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGD
KVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGK
VKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGT
SVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
 
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