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MGP000075

Record overview

MGPD IDMGP000075
Gene ID135
SpeciesHomo sapiens (Human)
Gene Nameadenosine A2a receptor
Gene Symbol ADORA2A
SynonymsA2aR; RDC8; ADORA2;
Alternate namesadenosine receptor A2a; adenosine receptor subtype A2a;
Chromosome22
Map Location22q11.23
SummaryThis gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
OrthologsView orthologs and multiple alignments for ADORA2A

Proteins

adenosine receptor A2a
Refseq ID:NP_001265426
Protein GI:511772965
UniProt ID:P29274
mRNA ID:NM_001278497
Length:412
RefSeq Status:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAI
DRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRI
FLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGL
DDPLAQDGAGVS
 
adenosine receptor A2a
Refseq ID:NP_001265427
Protein GI:511772967
UniProt ID:P29274
mRNA ID:NM_001278498
Length:412
RefSeq Status:
Protein sequence is identical to GI:511772965 (mRNA isoform)
 
adenosine receptor A2a
Refseq ID:NP_001265428
Protein GI:511772970
UniProt ID:P29274
mRNA ID:NM_001278499
Length:412
RefSeq Status:
Protein sequence is identical to GI:511772965 (mRNA isoform)
 
adenosine receptor A2a
Refseq ID:NP_000666
Protein GI:5921992
UniProt ID:P29274
mRNA ID:NM_000675
Length:412
RefSeq Status:
Protein sequence is identical to GI:511772965 (mRNA isoform)
 
adenosine receptor A2a
Refseq ID:NP_001265429
Protein GI:511772972
UniProt ID:P29274
mRNA ID:NM_001278500
Length:412
RefSeq Status:
Protein sequence is identical to GI:511772965 (mRNA isoform)
 
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