MGP Database

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MGP000081

Ontology/Pathway Information

Entrez Gene ID148
Gene Nameadrenoceptor alpha 1A
Gene Symbol ADRA1A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0031965 IDA:UniProtKBCnuclear membrane
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0030315 IEA:EnsemblCT-tubule
GO:0030018 IEA:EnsemblCZ disc
GO:0004937 NAS:UniProtKBFalpha1-adrenergic receptor activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0007202 ISS:BHF-UCLPactivation of phospholipase C activity
GO:0071875 ISS:GOCPadrenergic receptor signaling pathway
GO:0007512 IEA:EnsemblPadult heart development
GO:0007568 ISS:BHF-UCLPaging
GO:0006915 TAS:ProtIncPapoptotic process
GO:0060402 ISS:BHF-UCLPcalcium ion transport into cytosol
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0016049 IEA:EnsemblPcell growth
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0035556 TAS:ProtIncPintracellular signal transduction
GO:0060073 IEA:EnsemblPmicturition
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0001985 IEA:EnsemblPnegative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0035024 ISS:BHF-UCLPnegative regulation of Rho protein signal transduction
GO:0001994 IEA:EnsemblPnorepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0035265 IEA:EnsemblPorgan growth
GO:0007200 IEA:EnsemblPphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0097195 IEA:EnsemblPpilomotor reflex
GO:0045760 ISS:BHF-UCLPpositive regulation of action potential
GO:0060452 ISS:BHF-UCLPpositive regulation of cardiac muscle contraction
GO:0007204 ISS:BHF-UCLPpositive regulation of cytosolic calcium ion concentration
GO:0070374 ISS:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0001996 IEA:EnsemblPpositive regulation of heart rate by epinephrine-norepinephrine
GO:0043410 IDA:UniProtKBPpositive regulation of MAPK cascade
GO:0090037 ISS:BHF-UCLPpositive regulation of protein kinase C signaling
GO:0045987 IEA:EnsemblPpositive regulation of smooth muscle contraction
GO:0032230 ISS:BHF-UCLPpositive regulation of synaptic transmission, GABAergic
GO:0003084 IEA:EnsemblPpositive regulation of systemic arterial blood pressure
GO:0001997 IEA:EnsemblPpositive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0045907 ISS:BHF-UCLPpositive regulation of vasoconstriction
GO:0042493 ISS:BHF-UCLPresponse to drug
GO:0009725 ISS:BHF-UCLPresponse to hormone
GO:0007165 TAS:ProtIncPsignal transduction
GO:0006939 TAS:ProtIncPsmooth muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_16927Adrenoceptors
REACT_16983Amine ligand-binding receptors
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00367Carvedilol Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00368Labetalol Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
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