MGP Database

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MGP000085

Ontology/Pathway Information

Entrez Gene ID153
Gene Nameadrenoceptor beta 1
Gene Symbol ADRB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005769 IDA:UniProtKBCearly endosome
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0005634 IEA:EnsemblCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0031694 IPI:BHF-UCLFalpha-2A adrenergic receptor binding
GO:0004940 TAS:ProtIncFbeta1-adrenergic receptor activity
GO:0004939 TAS:ProtIncFbeta-adrenergic receptor activity
GO:0035240 IEA:EnsemblFdopamine binding
GO:0008144 IEA:EnsemblFdrug binding
GO:0051379 IEA:EnsemblFepinephrine binding
GO:0051380 IEA:EnsemblFnorepinephrine binding
GO:0030165 IPI:UniProtKBFPDZ domain binding
GO:0046982 IPI:BHF-UCLFprotein heterodimerization activity
GO:0005088 IDA:UniProtKBFRas guanyl-nucleotide exchange factor activity
GO:0005057 IDA:UniProtKBFreceptor signaling protein activity
GO:0007190 TAS:ProtIncPactivation of adenylate cyclase activity
GO:0071880 IDA:UniProtKBPadenylate cyclase-activating adrenergic receptor signaling pathway
GO:0007568 IEA:EnsemblPaging
GO:0006915 IEA:EnsemblPapoptotic process
GO:0050873 IEA:EnsemblPbrown fat cell differentiation
GO:0002024 IEA:EnsemblPdiet induced thermogenesis
GO:0042596 IEA:EnsemblPfear response
GO:0005980 IEA:EnsemblPglycogen catabolic process
GO:0031649 IEA:EnsemblPheat generation
GO:0055088 IEA:EnsemblPlipid homeostasis
GO:0007613 IEA:EnsemblPmemory
GO:0040015 IEA:EnsemblPnegative regulation of multicellular organism growth
GO:0045986 IEA:EnsemblPnegative regulation of smooth muscle contraction
GO:0035811 IEA:EnsemblPnegative regulation of urine volume
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0030819 IDA:UniProtKBPpositive regulation of cAMP biosynthetic process
GO:0043950 IDA:UniProtKBPpositive regulation of cAMP-mediated signaling
GO:2001259 IEA:EnsemblPpositive regulation of cation channel activity
GO:0061051 IEA:EnsemblPpositive regulation of cell growth involved in cardiac muscle cell development
GO:0001996 IEA:EnsemblPpositive regulation of heart rate by epinephrine-norepinephrine
GO:0032320 IDA:UniProtKBPpositive regulation of Ras GTPase activity
GO:1900135 IEA:EnsemblPpositive regulation of renin secretion into blood stream
GO:0046878 IEA:EnsemblPpositive regulation of saliva secretion
GO:0003084 IEA:EnsemblPpositive regulation of systemic arterial blood pressure
GO:0003061 IEA:EnsemblPpositive regulation of the force of heart contraction by norepinephrine
GO:0033365 IEA:EnsemblPprotein localization to organelle
GO:0051924 IEA:EnsemblPregulation of calcium ion transport
GO:0086004 IEA:EnsemblPregulation of cardiac muscle cell contraction
GO:0060080 IEA:EnsemblPregulation of inhibitory postsynaptic membrane potential
GO:0009409 IEA:EnsemblPresponse to cold
GO:0007266 IEA:EnsemblPRho protein signal transduction
GO:0019233 IEA:EnsemblPsensory perception of pain
GO:0002025 IEA:EnsemblPvasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0042060 IEA:EnsemblPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_16927Adrenoceptors
REACT_16983Amine ligand-binding receptors
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19327G alpha (s) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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