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MGP000085

UniProt Annotations

Entry Information
Gene Nameadrenoceptor beta 1
Protein EntryADRB1_HUMAN
UniProt IDP08588
SpeciesHuman
Comments
Comment typeDescription
DomainThe PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.
FunctionBeta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}.
InteractionQ86UL8:MAGI2; NbExp=2; IntAct=EBI-991009, EBI-311035; Q5TCQ9:MAGI3; NbExp=5; IntAct=EBI-991009, EBI-310506; P14270:Pde4d (xeno); NbExp=2; IntAct=EBI-991009, EBI-8333209;
PtmHomologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
SimilarityBelongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.
SubunitInteracts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4. {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:15358775}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/adrb1/";
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