MGP Database

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MGP000097

Ontology/Pathway Information

Entrez Gene ID177
Gene Nameadvanced glycosylation end product-specific receptor
Gene Symbol AGER
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 IEA:UniProtKB-SubCellCextracellular region
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0042802 IPI:IntActFidentical protein binding
GO:0004872 TAS:ProtIncFreceptor activity
GO:0044548 IPI:UniProtKBFS100 protein binding
GO:0004888 TAS:ProtIncFtransmembrane signaling receptor activity
GO:0007166 TAS:ProtIncPcell surface receptor signaling pathway
GO:0006954 TAS:ProtIncPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0031175 IGI:UniProtKBPneuron projection development
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0009611 TAS:ProtIncPresponse to wounding
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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