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MGP000097

UniProt Annotations

Entry Information
Gene Nameadvanced glycosylation end product-specific receptor
Protein EntryRAGE_HUMAN
UniProt IDQ15109
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q15109-1; Sequence=Displayed; Name=2; Synonyms=RAGESEC; IsoId=Q15109-2; Sequence=VSP_002551, VSP_002552; Name=3; IsoId=Q15109-3; Sequence=VSP_042011; Name=4; IsoId=Q15109-4; Sequence=VSP_043528, VSP_042011; Name=5; Synonyms=del exon3-7; IsoId=Q15109-5; Sequence=VSP_047884, VSP_047885; Name=6; IsoId=Q15109-6; Sequence=VSP_043528; Name=7; Synonyms=del exon3; IsoId=Q15109-7; Sequence=VSP_002551; Name=8; IsoId=Q15109-8; Sequence=VSP_047886, VSP_047888; Name=9; Synonyms=del exon8-9; IsoId=Q15109-9; Sequence=VSP_047887, VSP_047889; Name=10; Synonyms=delta-ICD, variant 20; IsoId=Q15109-10; Sequence=VSP_055321; Note=Detected in lung, brain, heart and kidney.;
FunctionMediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. {ECO:0000250, ECO:0000269|PubMed:19906677, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706}.
InteractionSelf; NbExp=2; IntAct=EBI-1646426, EBI-1646426; P62993:GRB2; NbExp=2; IntAct=EBI-1646426, EBI-401755; P16333:NCK1; NbExp=2; IntAct=EBI-1646426, EBI-389883; P61586:RHOA; NbExp=2; IntAct=EBI-1646426, EBI-446668; P04271:S100B; NbExp=5; IntAct=EBI-1646426, EBI-458391; P25815:S100P; NbExp=2; IntAct=EBI-1646426, EBI-743700; P02766:TTR; NbExp=2; IntAct=EBI-1646426, EBI-711909;
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular LocationIsoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Secreted.
SubunitInteracts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked. {ECO:0000250, ECO:0000269|PubMed:19386136, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:20947022, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706, ECO:0000269|PubMed:23284645}.
Tissue SpecificityEndothelial cells.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AGERID594ch6p21.html";
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