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MGP000106

Record overview

MGPD IDMGP000106
Gene ID203
SpeciesHomo sapiens (Human)
Gene Nameadenylate kinase 1
Gene Symbol AK1
SynonymsHTL-S-58j;
Alternate namesadenylate kinase isoenzyme 1; AK1; AK 1; myokinase; ATP:AMP phosphotransferase; ATP-AMP transphosphorylase 1; adenylate monophosphate kinase; testis secretory sperm binding protein Li 58j;
Chromosome9
Map Location9q34.1
EC Number2.7.4.3
SummaryAdenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AK1

Proteins

adenylate kinase isoenzyme 1
Refseq ID:NP_000467
Protein GI:4502011
UniProt ID:P00568
mRNA ID:NM_000476
Length:194
RefSeq Status:
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQ
QGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK
 
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