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MGP000106

UniProt Annotations

Entry Information
Gene Nameadenylate kinase 1
Protein EntryKAD1_HUMAN
UniProt IDP00568
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + AMP = 2 ADP. {ECO:0000255|HAMAP- Rule:MF_03171, ECO:0000269|PubMed:23416111}.
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate. {ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:23416111}.
DiseaseHemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631]: A disease characterized by hemolytic anemia and undetectable erythrocyte adenylate kinase activity. {ECO:0000269|PubMed:12649162, ECO:0000269|PubMed:2542324, ECO:0000269|PubMed:9432020}. Note=The disease is caused by mutations affecting the gene represented in this entry.
DomainConsists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
FunctionCatalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:23416111}.
PolymorphismThis enzyme represents the most common of at least five alleles.
SimilarityBelongs to the adenylate kinase family. AK1 subfamily. {ECO:0000255|HAMAP-Rule:MF_03171}.
Subcellular LocationCytoplasm.
SubunitMonomer. {ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|Ref.10, ECO:0000269|Ref.9}.
Web ResourceName=Wikipedia; Note=Adenylate kinase entry; URL="http://en.wikipedia.org/wiki/Adenylate_kinase";
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