MGP Database

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MGP000111

Ontology/Pathway Information

Entrez Gene ID211
Gene Name5'-aminolevulinate synthase 1
Gene Symbol ALAS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:HPACmitochondrion
GO:0005654 IDA:HPACnucleoplasm
GO:0003870 IEA:UniProtKB-ECF5-aminolevulinate synthase activity
GO:0030170 IEA:InterProFpyridoxal phosphate binding
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006783 TAS:ReactomePheme biosynthetic process
GO:0006778 TAS:ReactomePporphyrin-containing compound metabolic process
GO:0006782 IEA:UniProtKB-UniPathwayPprotoporphyrinogen IX biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_9465Heme biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_9431Metabolism of porphyrins
REACT_264351Mitochondrial biogenesis
REACT_264135Organelle biogenesis and maintenance
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_264212Transcriptional activation of mitochondrial biogenesis
SMP Pathway Links
SMP IDDescription
SMP007213-Phosphoglycerate dehydrogenase deficiency
SMP00344Acute Intermittent Porphyria
SMP00345Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
SMP00179Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
SMP00242Dimethylglycine Dehydrogenase Deficiency
SMP00484Dimethylglycinuria
SMP00004Glycine and Serine Metabolism
SMP00342Hereditary Coproporphyria (HCP)
SMP00485Hyperglycinemia, non-ketotic
SMP00223Non Ketotic Hyperglycinemia
SMP00346Porphyria Variegata (PV)
SMP00024Porphyrin Metabolism
SMP00244Sarcosinemia
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