MGP Database

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MGP000111

UniProt Annotations

Entry Information
Gene Name5'-aminolevulinate synthase 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13196-1; Sequence=Displayed; Name=2; IsoId=P13196-2; Sequence=VSP_025925, VSP_025924; Note=No experimental confirmation available.;
Catalytic ActivitySuccinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
MiscellaneousThere are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.
PathwayPorphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.
Sequence CautionSequence=CAA68506.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomodimer.
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