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MGP000118

Record overview

MGPD IDMGP000118
Gene ID218
SpeciesHomo sapiens (Human)
Gene Namealdehyde dehydrogenase 3 family, member A1
Gene Symbol ALDH3A1
SynonymsALDH3; ALDHIII;
Alternate namesaldehyde dehydrogenase, dimeric NADP-preferring; stomach aldehyde dehydrogenase; aldehyde dehydrogenase type III; aldehyde dehydrogenase isozyme 3;
Chromosome17
Map Location17p11.2
EC Number1.2.1.5
SummaryAldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
OrthologsView orthologs and multiple alignments for ALDH3A1

Proteins

aldehyde dehydrogenase, dimeric NADP-preferring
Refseq ID:NP_001128639
Protein GI:206597439
UniProt ID:P30838
mRNA ID:NM_001135167
Length:453
RefSeq Status:
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYI
HSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAA
AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSL
PFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
 
aldehyde dehydrogenase, dimeric NADP-preferring
Refseq ID:NP_000682
Protein GI:22907049
UniProt ID:P30838
mRNA ID:NM_000691
Length:453
RefSeq Status:
Protein sequence is identical to GI:206597439 (mRNA isoform)
 
aldehyde dehydrogenase, dimeric NADP-preferring
Refseq ID:NP_001128640
Protein GI:206597441
UniProt ID:P30838
mRNA ID:NM_001135168
Length:453
RefSeq Status:
Protein sequence is identical to GI:206597439 (mRNA isoform)
 
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